Neurofibromatosis (NF), which is a combination of three genetic diseases; NF1, NF2 and Schwannomatosis all result in the slow growth of typically Benign, non-Cancerous tumors, that can start to grow typically at birth, even if none are symptomatic till years later. While each type of NF results in different nerve types and formations, the commonality between NF types is the result of nerve damage from tumor growth. Individuals with NF1 and NF2 tumors can become Malignant, Cancerous.
Neurofibroma like Schwannoma grow attached to nerves, but in a different way. Cutaneous tumors are tumors that grow over the skin and but generally are not painful. Subcutaneous are tumors that grow anywhere under the skin and generally are painful.
While there can be more, the following are typical tumor types for each forms of NF.
NF1 results in Neurofibroma, Optic Glioma and Lisch nodules
The majority of NF2 tumors are within the Central Nervous System; brain and Spinal cord. NF2 results in Schwannoma, Meningioma, Ependymoma and Astrocytoma
Schwannomatosis results in Schwannoma - Schwannomatosis tumors are primarily:
Plotkin, S. R., Bredella, M. A., Cai, W., Kassarjian, A., Harris, G. J., Esparza, S., ... & Mautner, V. F. (2012). Quantitative assessment of whole-body tumor burden in adult patients with neurofibromatosis. PloS one, 7(4), e35711. http://dx.plos.org/10.1371/journal.pone.0035711
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