Tumor Suppressors

Last Updated: 03/30/17

  1. Inhibitors - Mechanism of Action
  2. Clinical Trials: Targeted Treatment
    • Drug-Based Treatments (all Clinical Trials)
    • Potential Future Clinical Trials
    • Determined Ineffective for NF2
  3. Phytotherapy: Botanicals
    • Over The Counter (OTC)
    • Not Publicly Available
    • Additional Substances

A tumor suppressor gene, or antioncogene, is a gene that protects a cell from one step on the path to become a tumor.

Currently no treatment has been proven to be 100% effective to destroy NF2 tumors or even simply stop all NF2 tumor growth in any individual; however several are in different stages of Clinical Trials of Chemotherapy type treatments. The goal with the Clinical Trial options is to treat all tumors at once and to date there have been a few options that have been found to have some success with certain tumor types and none of the options available works for everyone with NF2.

The only primary method of treatment for NF2 tumors is different forms of Microsurgery (Traditional Surgery) including but not limited to complete or partial tumor removal. The problem with any of the surgical options is it can typically only allow for treatment of one tumor at a time. This is a problem since it can take months to heal before another tumor can be addressed and individuals with NF2 might only have two tumors but it is not uncommon for people to have many more between the brain, spinal cord and body.

There are issues but occasional advantages to either Radiotherapy or Radiation treatment, however there can be long term consequences to these treatments. People with NF2 can have unique issues to these treatments, in comparison to people having Radiotherapy or Radiation Treatment for other reasons.(Please follow the link to understand advantages and disadvantages. )

It is difficult to determine effectiveness of chemotherapy with a long standing disease where individuals would already have had several treatments of other sorts that could cause conflicting data (Example of Radiotherapy or Radiation Treatments). Other chemotherapies and radiation therapies alone would affect how an individual responds to a treatment. [Fathi,2013]

The lack of ability to treat all tumors with the primary treatment of surgery means a molecular treatment is likely the answer to the cure for NF2. As the MERLIN Protein is the reason for NF2 tumor growth, "Gene Therapy and other types of treatments where we actually restore normal MERLiN function seems to be a good way to restore all of these functions back to normal."[Asthagiri,2015]

1. Inhibitors - Mechanism of Action


2. Clinical Trials: Targeted Treatment

No treatment for NF2 has been found effective for all tumor types or this section would be labeled, The Cure and since treatments at best sometimes alter 1 tumor type, these treatments are called Targeted Tumor Therapies. Some of the treatments sometimes Schwannoma tumors in some individuals for a period of time and a trial to help treat Ependymoma has just been started which has not gone far enough into early stages to know if it has helped anyone at all.

3. Phytotherapy: Botanicals

While the treatments in Clinical Trial for NF2 often have limited side effects, they are only limited in comparison to other medical tumor management treatments and still potentially dangerous to some level. Botanicals however can be use of a naturally grown plant or combination of plants taken as an extract or some other form, in the hope of slowing down or stopping tumor growth with no side effects if taken long term.

Reference Source

  1. Fathi, A. R., & Roelcke, U. (2013). Meningioma. Current neurology and neuroscience reports, 13(4), 1-8. http://link.springer.com/article/10.1007/s11910-013-0337-4
  2. Asthagiri M.D. National Institute of Health and NF2 Research. University of Virginia. 2015 NF2 Ohio Gathering. (2015) Section 6. MERLIN part in current Trial Limits, Paragraph 2. http://nf2is.org/Ohio_Gathering2015.php
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