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Neratinib (Nerlynx™)
Last Updated: 08/17/20
Angiogenesis Inhibitor
Also See: NF2 Informal Avastin Study
1. Basic Information
Neratinib (INN), sold under the brand name Nerlynx, is a tyrosine kinase inhibitor anti-cancer medication used for the treatment of breast cancer.[3][4]
Individuals with NF2 have and can remain on Avastin™ until; 1) side effects become dangerous or uncomfortable, 2) breaks for other medical treatments like surgeries are necessary, 3) proof of lack of tumor change, or 4) the treatment is no longer necessary.
To date, a few have managed to have Avastin™ may hold or slow down the growth of VS up to ten (10) years, but many stop the trial after two (2) years. A few left the trial for attempts at more effective trials, but in the last year, a few on Avastin starts a new trial of a combination of Avastin™ and other medications people have done well in trials in goals of better results.[1]
Awareness of possible side effects allow people to remain on Avastin™ longer.[1]
Avastin™ is not an approved treatment by the Food and Drug Administration (FDA) for NF2.
2. Delaying Avastin™ Side Effects
Major side effects are uncommon. Since people with NF2 are taking these medications at a low dose, only minimal side effects are common. However, following long term use is primarily where these major side effects take place. A blood and urine tests should be included the day of each treatment is necessary to review organ health that can help indicate recommendations in food or drinking habits that may be needed for continuation of treatment to prevent organ failure. Talk to your doctor.
- Hydration: Many of the side effects below are hydration issues; drink as much water as you can.
- Kidney Failure: In a urine test, this can be found if there is too much protein in urine. Look for dark colored urine.
- Gastrointestinal Perforation: Hole in Stomach, Small or Large Intestines. Symptoms - Abdominal Pain, Nausea, Vomiting, Constipation and Fever.
- Severe Bleeding: Coughing up Blood, Bleeding in the Stomach, Vomiting Blood, Bleeding in the Brain, Nosebleeds and Vaginal Bleeding.
- Dry Eyes resulting in Cracked Cornea: Make sure eyes stay lubricated with eye drops of some sort. Not limited to patients with dry eye issues prior to taking medications, but all people with NF2.
- Nausea: Nausea is easily managed with Zofran.
- Pregnancy: Doctors should include a discussion of freezing either eggs or sperm before starting treatment with all patients.
- Premature Ovarian Failure (POF) Early Menopause: Women should have FSH (Follicle-Stimulating Hormone) and Estradiol Levels regularly checked. - Learn More about POF
3. Possible Avastin™ Side Effects
List of Most Common Issues
- Dry Sinuses
- Dry Eyes
- Dry Skin
- Dry Throat
- Fatigue
- Headaches
- Impaired Wound Healing
- Irregular Menstrual Cycle
- Nausea
- Skin Rash
Complete Side Effects List
- Dry Sinuses
- Abdominal Pain
- Back Pain
- Bowel Perforation
- Brain Bleeding
- Cracked Cornea
- Dry Eyes
- Dry Skin
- Dry Throat
- Fatigue
- Headaches
- Heart Attack
- Heart Problems
- High Blood Pressure
- Hoarseness of Voice
- Impaired Wound Healing
- Inflammation of The Nose
- Irregular Menstrual Cycle
- Leg Pain
- Liver Failure
- Liver Problems
- Mouth Sores
- Nasal Septum Perforations
- Nausea
- Nephrotic Syndrome
- Nose Bleeds
- Premature Ovarian Failure
- Protein in Urine
- Rectal Bleeding
- Sensitive Tongue
- Skin Rash
- Stroke
- Taste Change
- Tear Production Disorder
4. Other Uses for Avastin™
Treatment for:
- Advanced non-small cell lung cancer (NSCLC)
- Metastatic colorectal cancer (mCRC)
- Metastatic kidney cancer (mRCC)
- Glioblastoma Multiforme (GBM)
- Breast Cancer, Metastatic
- Colorectal Cancer
- Glioblastoma Multiforme
- Macular Degeneration
- Malignant Glioma
- Neurofibromatosis Type 1
- Non-Small Cell Lung Cancer
- Ovarian Cancer
- Pancreatic Cancer
- Renal Cell Carcinoma
- Solid Tumors
