Brigatinib (Alunbrig™)
Last Updated: 12/5/24
Status: Solid Tumor and NF2 Clinical Trial
Administered By:
Pill - Oral (morning)
Tumor Target:
Solid Tumors; Schwannoma, Meningioma
Inhibits:
anaplastic lymphoma kinase (ALK) and
epidermal growth factor receptor (EGFR) inhibitor
Brigatinib (Alunbrig™) is a clinical trial tumor drug treatment listed for solid tumors.
Early mouse trial studies suggest brigatinib may have good results with the reduction of size in solid tumors including; schwannoma and meningioma.
During the mouse trials no growth was seen with long treatment breaks, followed by continued size reduction when the treatment continued
again later. If this holds for human trials, breaks for healing from possible side effects or for treatments of other health issues.
Treatment Availability
This solid tumor trial is available to individuals with neurofibromatosis type 2 (NF2), or other solid tumors.
Results in the Mouse Trial Phase
In mouse trials with brigatinib tumors reduced in size and remained stable during three (3) month breaks in treatment.
Side Effects
Common Side Effects
Risk or hepatotoxicity (Liver Damage), including drug-induced liver injury,
Muscle Cramps from Magnesium deficiency. While you can try food to meet the deficency, a person might need to take a Magnesium vitamin as well.
Food high in Magnesium
- Brazil Nuts
- Almonds
- Pecans
- Cashews
- Walnuts
- Pumpkin Seeds
- Flaxseeds
- Sunflower Seeds
- Sesame Seeds
- Quinoa Seeds (cooked)
- Cumin Seeds
- Cherries
- Peach
- Apricots
- Avocado
- Banana
- Blackberries
- Spinach
- Okra
- Broccoli
- Beetroot
- Swiss Chard
- Green Bell Peppers
- Artichokes
- Wild Rice
- Buckwheat
- Wheat Germ
- Oats
- Black-Eyed Peas
- Kidney Beans
- Yellow Corn
- Soybeans
- Brown Rice
- Wild Salmon
- Halibut
- Cocoa
- Whole Milk
- Molasses
- Cloves
- Prunes
- Coconut Water
- Almond Milk
Source Information
-
CTF. "Boston NF Symposium. 2019" (3/2019)
https://www.facebook.com/events/1266734493474401/
-
ChemSpider. "Brigatinib" ID34982928
-
Ozawa, Yuichi, et al. "Prospective observational study to explore genes and proteins predicting efficacy and safety of brigatinib for ALK-gene rearranged non-small-cell lung cancer:
study protocol for ABRAID study (WJOG11919L)." Therapeutic Advances in Medical Oncology 16 (2024): 17588359231225046.
Brigatinib in Patients With Crizotinib-Refractory Anaplastic Lymphoma Kinase-Positive Non-Small-Cell Lung Cancer: A Randomized, Multicenter Phase II Trial"
https://ascopubs.org/doi/full/10.1200/JCO.2016.71.5904
- Style Craze. "Top 42 Foods High In Magnesium To Include In Your Diet" (11/24/24))
https://www.stylecraze.com/articles/magnesium-rich-foods-you-should-include-in-your-diet/?sem_campaign=PMAXDynHealth_USA&gad_source=1&gclid=Cj0KCQiAuou6BhDhARIsAIfgrn7ISxNhqFlx4eJQRqkCM37L9FBAoq_Q2XIvkqyKQbX2PzyzOw-z2dkaAi4rEALw_wcB
- National Institute of Health: Magnesium "Top 42 Foods High In Magnesium To Include In Your Diet." (11/24/24))
https://ods.od.nih.gov/factsheets/Magnesium-Consumer/
-
Clinical Trials. "A Study to Compare the Relative Bioavailability of Brigatinib When Swallowed as a Solution Versus When Swallowed as a Tablet in Healthy Adults"
https://www.clinicaltrials.gov/study/NCT06132867?intr=Brigatinib&rank=1
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Clinical Trials. "A Study to Evaluate the Efficacy of Brigatinib (AP26113) in Participants With Anaplastic Lymphoma Kinase (ALK)-Positive, Non-small Cell Lung Cancer (NSCLC)
Previously Treated With Crizotinib"
https://www.clinicaltrials.gov/study/NCT02094573?intr=Brigatinib&rank=2
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Huang, Leyi, et al. "Magnesium Ion: A New Switch in Tumor Treatment." Biomedicines 12.8 (2024): 1717.
https://www.mdpi.com/2227-9059/12/8/1717#:~:text=An%20increase%20in%20the%20blood,inhibiting%20tumor%20growth%20%5B10%5D