Erlotinib (Tarceva™)

Last Updated: 03/28/17

Status: Currently a NF2 Clinical Trial


  1. Basic Information
  2. Trials
  3. Side Effects

1. Basic Information

Other Names Tarceva, N-(3-Ethynylphenyl)-6,7-bis(2-methoxyethoxy)quinazolin-4-amine, Erlotinib(Tarceva), nchembio866-comp3, 183321-74-6, CHEBI:114785
Pharmaceutical Companies Genetech, Roche and OSI Pharmaceuticals / Astellas
Trade Name Tarceva™
Treatment By Pill - Oral
Tumor Target Intracranial Schwannoma
Inhibitor Tyrosine Kinase Inhibitor a reversible tyrosine kinase inhibitor, which acts on the epidermal growth factor receptor (EGFR)
Molecular Formula C22H23N3O4
IUPAC N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)quinazolin-4-amine
ChemSpider CSID:154044
PubChem CID 176870

2. NF2 Trial

  • Single-agent Erlotinib in Patients Previously Treated With Oral Etoposide in Protocol OSI-774-205 -
  • A Study Comparing Sequential Satraplatin & Erlotinib to Erlotinib in Unresectable Stage 3/4 Non-Small-Cell Lung Cancer (NSCLC) -
  • Cetuximab in Patients With Lung Adenocarcinoma Receiving Erlotinib That Have Developed "Acquired Resistance" to Erlotinib -
  • Phase 2 Study of Maintenance OSI-906 Plus Erlotinib (Tarceva), or Placebo Plus Erlotinib in Patients With Nonprogression Following 4 Cycles of Platinum-based Chemotherapy -

3. Side Effects


Side Effects may Increase, tell your Doctor if you experience any of the following:

  • Diarrhea
  • Loss of Appetite
  • Nausea
  • Vomiting
  • Heartburn
  • Gas
  • Constipation
  • Stomach Pain
  • Mouth Sores
  • Weight Loss
  • Extreme Tiredness
  • Headache
  • Bone or Muscle Pain
  • Depression
  • Anxiety
  • Numbness, Burning, or Tingling of the Hands or Feet
  • Swelling of the Arms, Hands, Feet, Ankles, or Lower Legs
  • Darkening of Skin
  • Hair Loss
  • Change in Appearance of Hair and Nails

Serious Side Effects

  • Shortness of Breath
  • Cough
  • Fever or Chills
  • Chest Pain or Pressure
  • Pain in the Arms, Neck, or Upper Back
  • Rapid, Irregular, or Pounding Heartbeat
  • Slow or Difficult Speech
  • Dizziness or Faintness
  • Weakness or Numbness of an Arm or Leg
  • Unusual Bruising or Bleeding
  • Black and Tarry or Bloody Stools
  • Bloody Vomit or that looks like Coffee Grounds
  • Dry Mouth
  • Decreased Urination
  • Dark Urine
  • Pale or Yellow Skin
  • Redness, Warmth, Pain, Tenderness, or Swelling in One Leg
  • Skin Issues -
    • Rash (may look like acne and may affect the skin on the face, upper chest, or back
    • Blistering
    • Peeling
    • Dry
    • Cracked Skin
    • Itching
    • Tenderness
    • Burning
  • Eye Issues -
    • Dry Eyes
    • Red Eyes
    • Eye Pain
    • Irritated Eyes
    • Blurred Vision
    • Sunken Eyes
    • Growth of Eyelashes on the inside of the eyelid
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