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Lapatinib (Tykerb™)

Last Updated: 03/28/17

Status: Currently a NF2 Clinical Trial


  1. Basic Facts
  2. Other Uses
  3. Side Effects
  4. Warning
  5. Recommendations

1. Basic Information

Other Names Tykerb, Lapatinib Ditosylate, GW572016, 231277-92-2, GW 572016, Tycerb, 1xkk, Lapatinib (INN), Lapatinib [INN]
Trade Name Tykerb™
Pharmaceutical Company GlaxoSmithKline
Treatment By Pill - Oral
Tumor Target Vestibular Schwannoma
NF2 Trials
Inhibitor dual TKI Antineoplastic Agent - Tyrosine Kinase Inhibitor, interrupts the HER2/neu and Epidermal Growth Factor Receptor (EGFR) pathways
Molecular Formula C29H26ClFN4O4S
IUPAC N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[(2-methylsulfonylethylamino)methyl]-2-furyl]quinazolin-4-amine
ChemSpider 181006
PubChem CID 208908

2. Other Known Uses

Breast cancer and others.

3. Side Effects

Minimal Side Effects

Major side effects are uncommon. Since people with NF2 are taking these medications at a low dose, only minimal side effects are common. However, long term use is primarily where these major side effects take place. Monthly Blood and Urine Tests can usually point to an issue before it's a real problem. Talk to your doctor.

  • Memory Loss
  • Acne
  • Nail Infections
  • Vision - Light Sensitivity

Additional Side Effects to Watch for:

  • Liver Damage
  • Anemia
  • Low White Cell Count
  • Low Platlet Count
  • Risk of Infection
  • Nausea
  • Vomiting
  • Diarrhea
  • Belly Pain
  • Skin Irritation
  • Rash
  • Mouth Irritation
  • Numbness / Tingling of Hands and Feet
  • Fatigue
  • Irregular Menstrual Cycle

4. Warning:

Liver Damage: Look for dark urine, feeling tired, not hungry, nausea, vomiting or yellowing of skin and/or eyes.

5. Recommendations

Take Lapatinib at night instead of the morning to prevent fatigue.