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Everolimus (Afinitor™)

Last Updated: 01/18/18

Status: Currently a NF2 Clinical Trial

Chemical Structure, RAD001

Index

  1. Basic Facts
  2. Side Effects
  3. Other Uses

1. Basic Information

Other Names RAD-001, RAD001, Certican, Afinitor, Zortress, Sirolimus, SDZ-RAD, RAD001, Everolimus [USAN], RAD 001, Rapamycin, 42-O-(2-hydroxyethyl)-, UNII-9HW64Q8G6G
Trade Name Afinitor™ FermentekTM
Pharmaceutical Company Novartis
Tumor Target Vestibular Schwannoma
Treatment By Pill - Oral
NF2 Trials
Inhibitor mTOR Inhibitors (Mammalian Target of Rapamycin), effect is solely mTORC1 protein and not mTORC2 protein, similar to Sirolimus
Molecular Formula C53H83NO14
IUPAC Name dihydroxy-12-[(2R)-1-[(1S,3R,4R)-4-(2-hydroxyethoxy)-3-methoxycyclohexyl]propan-2-yl]-19,30-dimethoxy-15,17,21,23,29,35-hexamethyl-11,36-dioxa-4-azatricyclo[30.3.1.04,9]hexatriaconta-16,24,26,28-tetraene-2,3,10,14,20-pentone
Prescription Information DailyMed
PubChem CID 6442177
ChemSpider 21106307

2. Side Effects

Common Side Effects

  • Lung and Breathing Problems
  • Infections
  • Kidney Failure
  • Mouth Ulcers
  • Liver problems
  • Vaccinations - patients should not have live vaccinations while on Afinitor
  • Contraindicated with certain medications and certain foods

Additional Possible Side Effects:

  • Mouth Ulcers
  • Feeling Weak
  • Cough
  • Shortness of Breath
  • Diarrhea
  • Rash, Dry Skin, Itching
  • Nausea and Vomiting
  • Fever
  • Loss of Appetite
  • Swelling - Arms, Legs, Feet or Ankles
  • Infections - Respiratory Tract, Sinuses and Ears
  • Constipation
  • Stomach pain
  • Seizure
  • Headache
  • Dizziness
  • Stuffy / Runny Nose
  • change in personality
  • Low White Cell Count
  • High Fat Content in Blood

Infections, anemia, anorexia, hyperglycemia, hyperlipidemia, headache, pneumonitis, epistaxis, GI disorders

3. Other Uses

  • Advanced Kidney Cancer
  • Renal Transplantorgan Rejection Prevention
  • Subependymal Giant Cell Astrocytoma (SEGA)
  • Progressive / Metastatic Pancreatic Neuroendocrine Tumors
  • Breast Cancer

Sources