Sirolimus

Status: Potential NF2 Clinical Trial

1. Basic Description:

Sirolimus (INN/USAN), also known as Rapamycin, is an immunosuppressant drug used to prevent rejection in organ transplantation; it is especially useful in kidney transplants. Sirolimus is also a medication that has been in trial for NF2 tumors.

2. Unrelated Clinical Trials:

• Efficacy of Sirolimus In Liver Transplantation for Hepatocellular Carcinoma (HCC) - www.ClinicalTrials.gov
• A Pilot Study Evaluating the Use of mTor Inhibitor Sirolimus in Children and Young Adults With Desmoid-Type Fibromatosis - www.ClinicalTrials.gov

3. Serious Side Effects:

• Increase Risk of Infections or Cancer - Lymphoma (Cancer of the Immune System) and Skin Cancer
• If you had Liver or Lung Transplants, may cause serious side effects or death

Common Side Effects:

Fever Chills Frequent or Painful Urination Night Sweats Chest Pain General Pain Constant Weakness or Tiredness Fullness in the Stomach Unexplained Weight Loss Unusual Bleeding or Bruising Skin Issues - Sores Swelling Red Skin Racked Skin Hives Rash Itching Throat Issues - Trouble Breathing Swallowing Cough Sore Throat Hoarseness

Swelling - Neck Glands Armpits Groin Face Throat Tongue Lips Eyes Hands Feet Ankles Lower Legs

Edema, headache, fever, arterial hypertension, GI disorders, anemia, thrombocytopenia, hyperlipidemia, arthralgia, diabetes mellitus, infections

Additional Possible Side Effects:

• Headache
• Constipation
• Diarhhea
• Nausea
• Joint Pain

Sources

• Salido-Vallejo, R., G. Garnacho-Saucedo, and A. Vélez. "Elucidation of the mTOR pathway and therapeutic applications in dermatology." Actas Dermo-Sifiliográficas (English Edition) 107.5 (2016): 379-390.
  http://www.sciencedirect.com/science/article/pii/S1578219016300154 | https://doi.org/10.1016/j.adengl.2016.03.001